Ketamine Promotes Inflammation through Increasing TLR4 Expression in RAW264.7 Cells

• 作 者: 蒙臣 刘真 刘桂林 附丽莎 张敏 张曌 夏慧敏 张诗海 徐尤
• 机 构: DepartmentofAnesthesiology
• 出 处: 华中科技大学学报：医学英德文版
• 发表日期: 2015年3期
• 关键词: RAW264.7细胞 TLR4 炎症反应 氯胺酮 NMDA受体 TNF-α RT-PCR mRNA表达 ketamine toll-like receptor
• 基金项目: This project was supported by grants from the National Natu- ral Science Foundation of China （No. 30972837, and No. 81201454）.

Summery: Ketamine(KTM), a N-methyl-D-aspartate(NMDA) receptor antagonist, was found to has an anti-inflammatory effect, but some patients suffered from exacerbated pro-inflammatory reactions after anesthesia with KTM. The present study was aimed to examin