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β-内酰胺抗生素(如青霉素类和头孢菌素类等)可以专一性与细菌细胞膜上的靶位点结合,干扰细胞壁肽聚糖合成而导致细胞死亡。由于靶位点能与同位素标记的青霉素G进行共价结合,因此将这些靶位点称之为青霉素结合蛋白(Penicillin binding pro-teins,PBP’s)。一些革蓝氏阴性细菌和少数革蓝氏阳性菌能够产生多种β-内酰胺酶,这些酶可以水解青霉素和头孢菌素等抗生素,而使细胞具有抵抗这类β-内酰胺抗生素的杀伤能力。已经证明β-内酰胺酶产生与质粒和染色体基因有关。对于不产生β-内酰胺
β-lactam antibiotics (such as penicillins and cephalosporins, etc.) can be combined with the target site on the bacterial cell membrane, interfering with cell wall peptidoglycan synthesis and lead to cell death. Since target sites are capable of covalent binding to isotope-labeled penicillin G, these target sites are referred to as Penicillin binding pro-teins (PBP’s). Some gram-negative bacteria and a few gram-positive bacteria can produce a variety of β-lactamase, these enzymes can hydrolyze penicillin and cephalosporins and other antibiotics, leaving cells resistant to such β-lactam antibiotics kill ability . It has been demonstrated that β-lactamase production is associated with plasmid and chromosomal genes. For not producing β-lactam