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在多种动物已确定黄体生成素释放激素(LH-RH)及其高活性类似物具有抗生育作用,但其作用机理并未弄清。有作者提出,LH-RH的抗生育作用可能部分是由于其垂体外的作用,即直接作用于子宫的结果。但是,由于没有切除卵巢,不能排除LH-RH对子宫增重的影响系由于卵巢甾体生成变化的结果。因此本文作者在切垂体或切卵巢的动物观察了LH-RH及两种高活性类似物(WY-40,905及WY-40972)对子宫增重的影响。实验使用四种大鼠模型:(1)切垂体,5～6周后用于实验;(2)切卵巢,14天后用于实
Luteinizing hormone releasing hormone (LH-RH) and its highly active analogs have been shown to have anti-fertility effects in a variety of animals, but their mechanism of action is not clear. Some authors suggest that the anti-fertility effect of LH-RH may be due in part to its pituitary role, which is the result of direct action on the uterus. However, the effect of LH-RH on uterine weight gain can not be ruled out as a result of changes in ovarian steroidogenesis due to the absence of ovariectomy. Therefore, the authors observed the effects of LH-RH and two highly active analogues (WY-40,905 and WY-40972) on uterine weight gain in pituitary or ovariectomized animals. Four rat models were used in the experiment: (1) pituitary gland, 5 to 6 weeks later for experiment; (2) ovariectomy, 14 days later for real