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目的探讨血清半胱氨酸蛋白酶抑制剂C(Cys C)检测对糖尿病早期肾功能损害的诊断意义。方法将76例1型或2型糖尿病患者按尿白蛋白排泄率(UAER)分为3组(B、C、D组),20例无糖尿病的正常人为A组。其中,B组为正常蛋白尿患者31例(UAER<20μg/min),C组为微量蛋白尿患者28例(UAER 20～200μg/min),D组为大量蛋白尿患者17例(UAER>200μg/min)。同时测定各组血肌酐(Scr)及Cys C,并计算肌酐清除率(CCr)。结果 2型糖尿病各组血清Cys C水平与对照组相比明显升高,而且其水平随蛋白排泄率的升高而升高(P<0.05),而Scr在B组、C组间的差异无统计学意义(P>0.05)。结论 Cys C与糖尿病肾病的病情呈正相关,Cys C可作为2型糖尿病肾病患者早期监测的新指标。
Objective To investigate the diagnostic value of serum cystatin C (Cys C) in early diabetic patients with impaired renal function. Methods 76 patients with type 1 or type 2 diabetes were divided into 3 groups (group B, C and D) according to urinary albumin excretion rate (UAER), and 20 normal subjects without diabetes were divided into group A There were 31 patients with normal albuminuria in group B (UAER <20μg / min), 28 patients with albuminuria in group C (20-200μg / min of UAER), 17 patients with large albuminuria in group D (UAER> 200μg / / min). Serum creatinine (Scr) and Cys C were also measured in each group, and creatinine clearance (CCr) was calculated. Results Serum levels of Cys C in each group were significantly higher than those in control group (P <0.05), while the level of Scr in group B and C was no difference Statistical significance (P> 0.05). Conclusions Cys C is positively correlated with diabetic nephropathy, and Cys C is a new indicator of early monitoring of type 2 diabetic nephropathy.