Peroxisome proliferator activated receptors at the crossroad of obesity, diabetes, and pancreatic ca

• 作 者: Simone Polvani Mirko Tarocchi
• 机 构: DepartmentofExperimentalandClinicalBiomedicalSciences',MarioSerio',,ChirurgiaGeneraleOncologic
• 出 处: 世界胃肠病学杂志：英文版
• 发表日期: 2016年8期
• 关键词: Insulin PANCREATIC cancer ADIPOSE tissue METFORMIN Nuclear receptor Leptin ADIPO
• 基金项目: Fondo per gli Investimenti della Ricerca di Base,No.RBAP10MY35_002,Ente Cassa di Risparmio di Firenze,and Fior Gen ONLUS to Galli A

Pancreatic ductal adenocarcinoma(PDAC) is the fourth cause of cancer death with an overall survival of 5% at five years. The development of PDAC is characteristically associated to the accumulation of distinctive genetic mutations and is preceded by the e