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目的评价伽玛刀治疗大肠癌肝转移的近期疗效。方法选取于2009年6月-2013年7月在我院进行治疗的68例大肠癌肝转移患者,根据患者的病变大小和部位选用不同大小的准直器,按照50%以上的等剂量曲线来覆盖整个靶区,单次周边剂量给予3Gy-6Gy,确保周边总剂量控制在35Gy-50Gy,进行分割7-12次,每周控制在4次左右。结果患者的血清CEA经过有效的治疗后,明显下降,同时患者治疗前的Karnofsky评分为64.39±7.82分,治疗后患者的Karnofsky评分为80.39±8.97分,患者治疗前后结果对比有显著性差异(P<0.05),有统计学意义。患者治疗后随访结果显示,患者的三个月、半年、一年的生存情况分别如下:67(98.53%)、60(88.24%)、48(70.59%)。结论伽玛刀治疗大肠癌肝转移的近期疗效非常好,能够提高患者的生存质量,同时提高患者的治愈率,值得在临床上推广。
Objective To evaluate the short-term curative effect of gamma knife in the treatment of liver metastasis of colorectal cancer. Methods Seventy-six patients with liver metastases from June 2009 to July 2013 in our hospital were selected according to the lesion size and location of the patients and colloids of different sizes were selected according to the isodose curves of more than 50% Cover the entire target area, a single peripheral dose given 3Gy-6Gy, to ensure that the total peripheral dose control 35Gy-50Gy, split 7-12 times a week control in about 4 times. Results The patient’s serum CEA was significantly decreased after effective treatment. At the same time, the Karnofsky score before treatment was 64.39 ± 7.82 and the Karnofsky score after treatment was 80.39 ± 8.97. There was significant difference between before and after treatment (P <0.05), with statistical significance. The follow-up results of patients after treatment showed that the three-month, six-year and one-year survival of patients were as follows: 67 (98.53%), 60 (88.24%), 48 (70.59%). Conclusion Gamma knife treatment of colorectal liver metastases in the near future is very good, can improve the quality of life of patients, while improving the cure rate of patients, it is worth in the clinical promotion.