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目的分析微生态制剂和乳果糖联合治疗儿童功能性便秘的临床疗效和不良反应。方法 75例功能性便秘患儿随机分成两组:治疗组45例,对照组30例。对照组采用基础疗法,包括调整饮食、训练排便习惯及每日进行适量活动等;治疗组在此基础上加服微生态制剂和乳果糖溶液。治疗4周,停药后随访8周。采用症状评分方法评价疗效。结果治疗组总有效率为88.89%,对照组总有效率为46.67%,治疗组疗效优于对照组(P<0.01),且远期复发率较对照组低(7.5%vs78.6%)(P<0.01);两组在治疗前后均进行大便pH值测定,治疗组差异有高度统计学意义(P<0.01),而对照组差异无统计学意义(P>0.05);治疗组有1例出现轻度腹泻,两组未发现其他不良反应。结论微生态制剂和乳果糖联合治疗儿童功能性便秘疗效显著。
Objective To analyze the clinical efficacy and adverse reactions of probiotics combined with lactulose in children with functional constipation. Methods 75 cases of functional constipation were randomly divided into two groups: treatment group 45 cases, control group 30 cases. The control group used basic therapy, including diet, training of bowel habits and daily exercise; the treatment group supplemented with probiotics and lactulose solution. Treatment for 4 weeks, followed up for 8 weeks after stopping. Symptom evaluation method to evaluate the efficacy. Results The total effective rate was 88.89% in the treatment group and 46.67% in the control group. The curative effect of the treatment group was better than that of the control group (P <0.01), and the long-term recurrence rate was lower than that of the control group (7.5% vs 78.6%) P <0.01). Before and after treatment, the stool pH values were measured in both groups. There was a statistically significant difference between the two groups (P <0.01), but there was no significant difference in the control group (P> 0.05) Mild diarrhea, no other adverse reactions were found in both groups. Conclusion The combination of probiotics and lactulose has a significant therapeutic effect on children with functional constipation.