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目的:系统地探讨在尿毒症不宁腿综合征的治疗中应用左卡尼汀与多巴丝肼联合疗法的实际价值。方法:选取茂名市中医院收治的120例尿毒症伴不宁腿综合征患者进行分组研究,结合临床随机表法将其平均地列入观察组与对照组,对照组仅使用左卡尼汀进行治疗,在对照组基础上,观察组加用多巴丝肼,对比两组患者治疗前后的不宁腿综合征评分,借助于多导睡眠图对比两组周期性肢动指数及微觉醒指数,记录两组不良反应的发生情况。结果:治疗后,两组患者不宁腿综合征评分、周期性肢动指数及微觉醒指数比较,差异具有统计学意义(P<0.05);两组均不存在心、肝损害等严重不良反应。结论:在尿毒症不宁腿综合征的治疗中,左卡尼汀与多巴丝肼联合疗法安全有效。
Objective: To systematically explore the practical value of the combination therapy of levocarnitine and dobesilazin in the treatment of urethritis restless legs syndrome. Methods: A total of 120 uremia patients with restless legs syndrome admitted to Maoming Traditional Chinese Medicine Hospital were divided into observation group and control group according to the randomized clinical trial. The control group was treated with L-carnitine alone On the basis of the control group, the observation group was treated with doppler hydrazide, and the restless legs syndrome score was compared between the two groups before and after treatment. The polysomnographic index and arousal index of the two groups were compared by polysomnography, Record the incidence of adverse reactions in both groups. Results: After treatment, the scores of restless legs syndrome, periodic extremity index and arousal index in two groups were significantly different (P <0.05). There were no serious adverse reactions such as heart and liver damage in both groups . Conclusion: L-carnitine combined with doppler hydrazide is safe and effective in the treatment of urethritis restless legs syndrome.