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骨髓抑制是成人急性淋巴细胞白血病(ALL)有效的诱导化疗相关的剂量限制性毒性,是导致感染的重要原因。在诱导化疗期,感染引起的死亡率与年龄有关,年青人约3％,50～60岁的老年人死亡率>20％。细胞减少常常迫使化疗推迟。本研究对成人ALL在诱导化疗时给予粒细胞集落刺激因子(G-CSF),是否可防止治疗相关的中性粒细胞减少和感染的发生以及因而导致的化疗的推迟。 病人与方法 患者是1992年1月～1993年4月来自19个中心的新诊断病人。本文属前瞻性、随机性Ⅲ期研究,按方案完成头4周的Ⅰ期诱导化疗后,达到完全
Myelosuppression is an effective dose-limiting toxicity associated with induction chemotherapy in adults with acute lymphoblastic leukemia (ALL) and is an important cause of infection. In the induction chemotherapy period, the mortality caused by infection is related to age, with about 3% of young people, and the mortality rate of older people aged 50-60 years is >20%. Decrease often forces chemotherapy to be delayed. This study investigated whether administration of granulocyte colony-stimulating factor (G-CSF) to adult ALL during induction chemotherapy prevents the development of treatment-associated neutropenia and infection and the resulting delay in chemotherapy. Patients and Methods Patients were newly diagnosed patients from 19 centers from January 1992 to April 1993. This article is a prospective, randomized phase III study, complete after the first 4 weeks of phase I induction chemotherapy as per protocol