Munc18/SNARE proteins’ regulation of exocytosis in guinea pig duodenal Brunner’s gland acini

• 作 者: Laura I Cosen-Binker Gerry P M
• 机 构: DepartmentofMedicine,GastrointestinalDiseasesResearchUnit
• 出 处: 世界胃肠病学杂志：英文版（电子版）
• 发表日期: 2008年15期
• 关键词: 胞吐作用 腺核 十二指肠 蛋白质调节 Apical exocytosis Brunner＇s gland acini Munc18c Syntaxin-4
• 基金项目: Grants to H.Y.G. from the U.S. National Institute of Health, R21 AA015579-01A1 and to S.V. form the Canadian Institute of Health Research.

AIM: To examine the molecular mechanism of exocytosis in the Brunner’s gland acinar cell. METHODS: We used a submucosal preparation of guinea pig duodenal Brunner’s gland acini to visualize the dilation of the ductal lumen in response to cholinergic stimu