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为探讨胃癌患者血清层粘连蛋白 (LN)和Ⅳ型胶原 (Ⅳ -C)变化规律及其意义 ,本文应用放射免疫分析方法测定 2 0例胃癌患者及 15例对照病人血清LN、Ⅳ -C浓度。结果表明胃癌患者血清LN、Ⅳ -C含量均显著高于对照组 ,升高比例为 4 4 4 %和 55 0 %。进展期 (TNMⅡ、Ⅲ、Ⅳ期 )胃癌二者血清含量较早期 (TNMⅠ期 )明显升高 ,有淋巴结转移的较无转移者高。但肿瘤各组织细胞学类型间二者水平均未见统计学差异。结果提示胃癌患者血清LN、Ⅳ -C含量与肿瘤的浸润及转移有密切关系 ,观察血清LN、Ⅳ -C含量及变化 ,对胃癌患者的病情及预后判断有重要参考价值。
In order to explore the changes and significance of serum laminin (LN) and collagen Ⅳ (IV-C) in gastric cancer patients, we used radioimmunoassay to detect the serum levels of LN and IV-C in 20 gastric cancer patients and 15 control patients . The results showed that the serum levels of LN and IV-C in patients with gastric cancer were significantly higher than those in the control group (44.4% and 55.0%, respectively). The serum levels of both advanced stage (TNMⅡ, Ⅲ, Ⅳ) gastric cancer were significantly higher than those in the early stage (TNMⅠstage), and those with lymph node metastasis were higher than those without metastasis. However, there was no statistical difference between the two cytology types in tumor tissues. The results suggest that the serum levels of LN and Ⅳ -C in gastric cancer patients are closely related to the invasion and metastasis of gastric cancer. The contents and changes of serum LN and Ⅳ -C in serum of patients with gastric cancer have important reference values for the prognosis and prognosis of gastric cancer patients.