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目的探讨白细胞介素18(IL-18)、可溶性血管黏附分子-1(sVCAM-1)和血管内皮生长因子(VEGF)水平变化与系统性红斑狼疮(SLE)发病机制的关系。方法采用酶联免疫ELISA法检测SLE患者35例,正常对照组25例血清IL-18、sVCAM-1和VEGF的水平。结果SLE组IL-18(521.23±134.29)pg/mL、sVCAM-1(1179.25±225.57)ng/mL、VEGF(198.85±41.96)pg/mL,较正常对照组IL-18(256.39±59.52)pg/mL、sVCAM-1(538.16±91.21)ng/mL、VEGF(125.62±32.15)pg/mL明显升高,差异有统计学意义(P均<0.01)。活动期SLE患者IL-18(687.44±158.60)pg/mL、sVCAM-1(1478.14±322.72)ng/mL、VEGF(236.25±48.62)pg/mL与非活动期组SLEIL-18(355.02±109.98)pg/mL、sVCAM-1(881.37±128.30)ng/mL、VEGF(160.47±35.79)pg/ml之间比较,差异有统计学意义(P均﹤0.01)。结论SLE患者IL-18、sVCAM-1和VEGF水平增高,且与疾病的活动性相关。
Objective To investigate the relationship between the levels of interleukin 18 (IL-18), soluble vascular adhesion molecule-1 (sVCAM-1) and vascular endothelial growth factor (VEGF) and the pathogenesis of systemic lupus erythematosus (SLE) Methods Serum levels of IL-18, sVCAM-1 and VEGF in 35 SLE patients and 25 normal controls were detected by enzyme linked immunosorbent ELISA. Results Compared with normal control group, IL-18 (521.23 ± 134.29) pg / mL, sVCAM-1 (1179.25 ± 225.57) ng / mL and VEGF / mL, sVCAM-1 (538.16 ± 91.21) ng / mL, VEGF (125.62 ± 32.15) pg / mL was significantly increased, the difference was statistically significant (P all <0.01). The activity of IL-18 (687.44 ± 158.60) pg / mL and sVCAM-1 (1478.14 ± 322.72) ng / mL and VEGF (236.25 ± 48.62) pg / mL and inactive SLEIL-18 (355.02 ± 109.98) pg / mL, sVCAM-1 (881.37 ± 128.30) ng / mL and VEGF (160.47 ± 35.79) pg / ml respectively. There was significant difference between them (all P <0.01). Conclusion The levels of IL-18, sVCAM-1 and VEGF in patients with SLE are increased, and are related to the activity of the disease.