论文部分内容阅读
系统性肥大细胞病(SM)是一种慢性干细胞疾患,表现为皮肤、实质性器官和骨髓肥大细胞数量增多。75％的病例临床及放射学上有骨质疏松的证据。目前,SM相关性骨质疏松症尚无十分有效的治疗手段,本文报道采用α-2b干扰素(α-2bIFN)成功治疗3例SM相关性严重骨质疏松症。 3例均为成年患者,男2例,女1例。2例有色素性荨麻疹,2例因椎骨压缩性骨折出现严重背部疼痛。α-2bIFN的使用:第1天100万单位,逐渐增加至第5天的500万单位,皮下注射,以后每周3次,时间不少于6个月。在IFN治疗前及治疗后6个月重复骨髓活
Systematic mastocytosis (SM) is a chronic stem cell disorder characterized by an increase in the number of skin, substantial organs, and myeloid mast cells. Clinical and radiographic evidence of osteoporosis is present in 75% of cases. At present, there is no effective treatment for SM-related osteoporosis. We report the successful treatment of 3 cases of SM-related severe osteoporosis with α-2b interferon (α-2bIFN). 3 cases were adult patients, 2 males and 1 female. 2 cases had uveal uveal, 2 cases of severe back pain due to vertebral compression fractures. α-2bIFN use: 1 million units on the first day, gradually increased to 5 million units on the 5th day, subcutaneous injection, after three times a week, the time of not less than 6 months. Bone marrow activity was repeated before IFN treatment and 6 months after treatment