论文部分内容阅读
目的探讨乙肝免疫球蛋白(HBIG)与乙肝疫苗联合免疫对HbsAg、HbeAg单阳性及双阳性孕妇所生新生儿预后的影响。方法试验组孕妇自怀孕28w起每4w注射HBIG 200IU,新生儿出生8h内、15天各注射HBIG 200IU,同时按0、1、6月顺序接种乙肝疫苗(每次剂量5μg)。对照组新生儿仅按0、1、6月顺序接种乙肝疫苗。观察两组中新生儿HBV感染情况。结果HBV病毒携带者中,HbeAg阴性的试验组与对照组新生儿HBV感染差异无显著性;HbeAg阳性的试验组与对照组新生儿HBV感染差异有显著性。结论应用乙肝免疫球蛋白与乙肝疫苗联合免疫能有效阻断HBV母婴传播的产前和产后感染,并降低宫内感染率,对新生儿预后较好。
Objective To investigate the effects of combined immunization with hepatitis B immunoglobulin (HBIG) and hepatitis B vaccine on the prognosis of newborn infants born to HbsAg, HbeAg single positive and double positive pregnant women. Methods Pregnant women in the experimental group were injected with 200 IU of HBIG every 4 weeks from the 28th week of pregnancy and 200 IU of HBIG were injected within 8 hours and 15 days of the newborn respectively. At the same time, hepatitis B vaccine (5μg / dose) was vaccinated in the order of 0, 1 and 6 months. The control group of newborns were vaccinated with hepatitis B vaccine only in the order of 0, 1 and 6 months. Neonatal HBV infection was observed in both groups. Results Among HBV carriers, there was no significant difference in neonatal HBV infection between HbeAg negative control group and control group. There was a significant difference in neonatal HBV infection between HbeAg positive control group and control group. Conclusion Combined immunization with hepatitis B immunoglobulin and hepatitis B vaccine can effectively block the transmission of HBV prenatal and postnatal HBV infection and reduce the intrauterine infection rate.