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目的探讨河南地区无偿献血者中性粒细胞特异性(HNA)抗体的分布和特异性,分析HNA抗体引起的免疫性输血不良反应。方法随机收集女性标本156例,男性标本80例,采用LABScreen Multi试剂盒对标本HNA抗体进行检测。结果 236例无偿献血者中,女性HNA抗体检出阳性率为5.77%(9/156),男性为5.00%(4/80)。其中HNA 1A者7例,HNA4A者4例,同时检出HNA 1A和HNA 4A、HNA 1A和HNA 1C各1例。结论 HNA抗体分布无性别差异,研究HNA抗体的分布和特异性,可为指导临床用血安全和相关政策的制定提供有力的理论基础。
Objective To investigate the distribution and specificity of neutrophil-specific (HNA) antibodies in blood donors in Henan, and to analyze the adverse reactions induced by HNA antibodies. Methods A total of 156 female specimens and 80 male specimens were randomly collected. The specimens were tested for HNA antibodies using the LAB Screen Multi Kit. Results Among the 236 unpaid blood donors, the positive rate of female HNA antibody detection was 5.77% (9/156) and that of male was 5.00% (4/80). There were 7 cases of HNA 1A and 4 cases of HNA4A. One case of HNA 1A and HNA 4A, HNA 1A and HNA 1C was detected at the same time. Conclusion There are no gender differences in the distribution of HNA antibodies. Studying the distribution and specificity of HNA antibodies can provide a powerful theoretical basis for guiding the development of blood safety and related policies in clinical practice.