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目的分析十堰地区不孕不育女性患者的染色体核型,为临床不孕不育症的治疗提供参考依据。方法选取2013年2月-2016年2月在十堰市太和医院就诊的不孕不育患者1 200例为研究对象,对其进行染色体核型分析。结果 1 200例不孕不育患者中,检出染色体核型异常71例,占5.9%。其中常染色体核型异常44例,占核型异常的62.0%,包括染色体结构异常18例(25.4%),染色体多态性26例(36.6%);性染色核型异常27例,占核型异常的38.0%,包括染色体数目异常17例(23.9%),染色体结构异常2例(2.8%),染色体多态性8例(11.3%)。结论染色体结构、数目异常及多态性是导致女性不孕不育的关键因素,针对女性异常的染色体进行核型分析,可更准确的判断其病因。
Objective To analyze the karyotypes of infertile female patients in Shiyan area and provide references for clinical infertility treatment. Methods From January 2013 to February 2016, 1 200 cases of infertility patients treated in Taihe Hospital of Shiyan were selected as the research object, and their karyotypes were analyzed. Results In 1 200 cases of infertility patients, 71 cases were detected karyotype abnormalities, accounting for 5.9%. There were 44 autosomal abnormalities, accounting for 62.0% of the abnormalities, including 18 (25.4%) chromosomal abnormalities, 26 (36.6%) chromosomal abnormalities, 27 abnormal karyotypes Abnormal 38.0%, including 17 cases of chromosomal abnormalities (23.9%), chromosomal abnormalities in 2 cases (2.8%), chromosome polymorphism in 8 cases (11.3%). Conclusions Chromosomal structure, number abnormality and polymorphism are the key factors leading to female infertility. Karyotype analysis of abnormal female chromosomes can be more accurate to determine the etiology.