论文部分内容阅读
[目的]对比不同给药方案对功能性消化不良(FD)患者的疗效。[方法]将我院收治的149例FD患者依据用药方案差异随机分为2组,其中74例单用盐酸伊托必利治疗设为对照组,其余75例将盐酸伊托必利联合泮托拉唑钠肠溶微丸胶囊治疗设为观察组,对比2组4周后的疗效、复发率与不良反应情况。[结果]2组用药4周后总有效率为83.78%和96.00%,对照组远不及观察组效果理想(P<0.05);观察组在用药1、3、6个月后复发率分别为8.00%、17.33%、24.00%,对照组在此时间点复发率分别为9.46%、21.62%、41.89%,组间在用药6个月后复发率差异明显(P<0.05);2组均未见1例与用药相关的不良反应症状。[结论]采用泮托拉唑钠肠溶微丸胶囊联合盐酸伊托必利治疗FD,效果理想且远期观察复发率较低,患者无明显不良反应,值得临床推广。
[Objective] To compare the efficacy of different dosage regimens in patients with functional dyspepsia (FD). [Methods] A total of 149 FD patients admitted to our hospital were randomly divided into two groups according to the difference of drug regimen. Among them, 74 cases were treated with Itopride Hydrochloride alone, and the remaining 75 cases were treated with Itopride Hydrochloride The treatment of rabeprazole sodium enteric-coated micro-capsules was set as the observation group, comparing the curative effect, recurrence rate and adverse reactions of the two groups after 4 weeks. [Results] The total effective rates of the two groups were 83.78% and 96.00% after 4 weeks of treatment, and the control group was far less effective than the observation group (P <0.05). The recurrence rates of the observation group after 1, 3 and 6 months were 8.00 %, 17.33% and 24.00%, respectively. The recurrence rates of the control group were 9.46%, 21.62% and 41.89% respectively at this time point. The recurrence rates of the control group at 6 months after treatment were significantly different (P <0.05) 1 case of drug-related adverse reaction symptoms. [Conclusion] The use of pantoprazole sodium enteric-coated pellets combined with itoprime hydrochloride in the treatment of FD is ideal and long-term observation of recurrence rate is low, the patient no obvious adverse reactions, is worth clinical promotion.