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目的探讨转化生长因子(TGF)-β_1和血管内皮生长因子(VEGF)在胃癌组织中的表达及临床意义。方法选择新乡市第二人民医院自2015年1月至2016年6月收治的110例胃癌患者为研究对象,所有患者均接受手术治疗并取肿瘤组织,采用免疫组化技术检测胃癌组织与癌旁组织中的TGF-β_1和VEGF水平,分析其与患者临床特征之间的关系。结果胃癌组织中TGF-β_1(65.45%vs 11.82%,χ~2=12.063)和VEGF(70.91%vs 14.55%,χ~2=15.154)的阳性率均明显高于癌旁组织,差异均有统计学意义(均P<0.05)。胃癌组织中TGF-β_1和VEGF水平与临床分期和有无淋巴结转移有密切联系(均P<0.05),与年龄和性别无明显关系(均P>0.05)。结论胃癌组织中TGF-β_1和VEGF表达明显增多,检测胃癌组织中TGF-β_1和VEGF水平有助于协助诊断胃癌,值得在临床中推广应用。
Objective To investigate the expression of transforming growth factor (TGF) -1 and vascular endothelial growth factor (VEGF) in gastric carcinoma and its clinical significance. Methods 110 patients with gastric cancer admitted to the Second People’s Hospital of Xinxiang City from January 2015 to June 2016 were enrolled in this study. All patients underwent surgical treatment and tumor tissue was taken. Immunohistochemistry was used to detect the correlation between gastric cancer tissues and adjacent tissues The levels of TGF-β 1 and VEGF in tissues were analyzed for their relationship to the clinical characteristics of the patients. Results The positive rates of TGF-β 1 (65.45% vs 11.82%, χ ~ 2 = 12.063) and VEGF (70.91% vs 14.55%, χ ~ 2 = 15.154) in gastric cancer tissues were significantly higher than those in paracancerous tissues Significance (both P <0.05). The levels of TGF-β_1 and VEGF in gastric cancer tissues were closely related to clinical stage and lymph node metastasis (all P <0.05), but not to age and sex (all P> 0.05). Conclusion The expression of TGF-β 1 and VEGF in gastric cancer tissues is significantly increased. Detecting the levels of TGF-β 1 and VEGF in gastric cancer tissue is helpful to diagnose gastric cancer, which is worth popularizing in clinic.