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肾小球硬化是多种生物活性物质、多种细胞成分引起肾小球损伤后出现的一种渐进性病理过程,肾脏局部和机体系统的环境都可以影响其发生发展;是细胞外基质(extracelluar matrix,ECM)逐渐增多和肾小球系膜细胞(glomerular mesangial cells,GMC)增殖的结果[1]。ECM主要包括胶原蛋白
Glomerulosclerosis is a progressive pathological process after a variety of cellular components cause glomerular injury. Local and systemic conditions in the kidney can affect its development. It is an extracellular matrix matrix, ECM) and glomerular mesangial cells (glomerular mesangial cells, GMC) proliferation [1]. ECM mainly includes collagen