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目的:观察西地那非联合常频呼吸机治疗新生儿持续肺动脉高压的疗效。方法:选择2007年6月～2011年5月持续性肺动脉高压新生儿43例,随机分为西地那非组20例和单纯呼吸机组23例,比较两组的有效率和治疗前后临床指标的变化情况。结果:单纯呼吸机组总有效率为63.0%,无效9例,其中气胸4例,放弃5例;西地那非组总有效率为85.0%,无效3例,其中气胸1例,放弃2例。两组患儿治疗后临床症状好转,PAMP逐渐下降,SaO2和PaO2逐渐上升,与治疗前比较差异有统计学意义。所有患儿在西地那非治疗过程中未见不良反应。结论:口服西地那非对于新生儿持续肺动脉高压治疗效果明显,可以降低PAMP,改善心功能,缓解临床症状,值得临床推广。
Objective: To observe the efficacy of sildenafil combined with continuous-frequency ventilator in the treatment of neonatal pulmonary hypertension. Methods: Forty-three neonates with persistent pulmonary hypertension were selected from June 2007 to May 2011. They were randomly divided into two groups: 20 cases of sildenafil and 23 cases of simple ventilator. The clinical data of two groups were compared before and after treatment Changes. Results: The total effective rate of simple breathing unit was 63.0%, 9 cases were ineffective, including 4 cases of pneumothorax and 5 cases of abandonment. The total effective rate of sildenafil group was 85.0%, 3 cases were ineffective, 1 case of pneumothorax and 2 cases of abandonment. After treatment, the clinical symptoms of both groups improved, PAMP gradually decreased, SaO2 and PaO2 gradually increased, with statistical significance before treatment. All children had no adverse reactions during sildenafil treatment. Conclusion: Oral sildenafil is effective in treating neonatal persistent pulmonary hypertension, which can reduce PAMP, improve cardiac function and relieve clinical symptoms, which is worthy of clinical promotion.