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目的探讨职业性铅暴露对工人血脂质过氧化及抗氧化酶的影响。方法选择广西某冶炼厂53名铅作业工人为暴露组,不接触铅烟尘及其他有害物质的志愿者66名为对照组,测定血铅(BPb)、血清丙二醛(MDA)含量及超氧化物歧化酶(SOD)、谷胱甘肽过氧化物酶(GSH-Px)活力。结果作业场所空气中铅烟平均浓度为0.43 mg/m3(0.05~1.65 mg/m3),铅尘平均浓度为0.44 mg/m3(0.02~1.15 mg/m3),均超过时间加权平均容许浓度。暴露组BPb含量高于对照组,400μg/L≤BPb<600μg/L组血清SOD活力高于BPb<200μg/L组,BPb≥600μg/L组血清SOD活力低于其他各组,BPb≥600μg/L组血清GSH-Px活力低于400μg/L≤BPb<600μg/L组,差异均有统计学意义(P<0.05或P<0.01)。结论400μg/L≤BPb<600μg/L时,可引起血清SOD活力增高;BPb≥600μg/L时则引起血清SOD、GSH-Px活力明显降低,提示,铅有自由基毒性。
Objective To investigate the effects of occupational lead exposure on blood lipid peroxidation and antioxidant enzymes in workers. Methods Fifty-three lead workers in a smelter in Guangxi were selected as the control group and 66 volunteers who were exposed to lead dust and other harmful substances as the control group. The levels of blood lead (BPb), serum malondialdehyde (MDA) and superoxide SOD, GSH-Px activity. Results The average concentration of lead in the air of workplace was 0.43 mg / m3 (0.05-1.65 mg / m3) and the average lead dust concentration was 0.44 mg / m3 (0.02-1.15 mg / m3), all exceeding the time weighted average allowable concentration. The activity of SOD in serum of the exposed group was higher than that of the control group, the activity of SOD in 400μg / L≤BPb <600μg / L group was higher than that of BPb <200μg / L group, BPb≥600μg / L, BPb≥600μg / The activity of GSH-Px in group L was lower than 400μg / L≤BPb <600μg / L, the differences were statistically significant (P <0.05 or P <0.01). Conclusions When 400μg / L≤BPb <600μg / L, serum SOD activity can be increased. When BPb≥600μg / L, the activity of SOD and GSH-Px in blood serum is significantly decreased, suggesting that lead has free radical toxicity.