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为了维持和调节细胞内外Na~+、K~+浓度梯度和膜电位,细胞膜的Na~+泵(Na~+、K~+-ATP酶)起着重要作用。强心药洋地黄能与Na~+泵特异结合,增加细胞内Na~+、Ca~(++)而发挥强心作用。体内的Na~+泵调节物质也能与Na~+泵结合,被命名为内源性洋地黄样物质(EDF)。EDF与肾排Na~+和小血管紧张等高血压病和慢性肾功不全的病理生理有关。由于肾和血管的Na~+、K~+-ATP酶抑制,推测可导致Na~+利尿和血管收缩。EDF的测定多据洋地黄生物活性和抗洋地黄血清的免疫交叉活性等进行,但各种方法均不能排除非特异物质的干扰。原发性高血压和动物实验性高血压
In order to maintain and regulate intracellular Na ~ +, K ~ + concentration gradient and membrane potential, the membrane Na ~ + pump (Na ~ +, K ~ + -ATPase) plays an important role. Cardiotoxic drug digitalis with Na ~ + pump specific binding, increase intracellular Na ~ +, Ca ~ (++) and exert a cardiac effect. In vivo Na ~ + pump regulators can also be combined with Na ~ + pumps and are named endogenous digitalis-like substances (EDFs). EDF and kidney row Na ~ + and other small blood vessels and hypertension and chronic renal insufficiency pathophysiology. Due to renal and vascular Na ~ +, K ~ + -ATPase inhibition, presumably lead to Na ~ + diuretic and vasoconstriction. EDF determination of digitalis biological activity and anti-digitalis anti-immune cross-reactivity, etc., but a variety of methods can not rule out the interference of non-specific substances. Essential hypertension and animal experimental hypertension