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目的探讨特比萘芬加联苯苄唑乳膏即“1+1”疗法联合治疗足癣的疗效。方法采用特比萘芬加联苯苄唑乳膏联合治疗足癣78例,并与单一口服特比萘芬治疗足癣(76例)和单一外用联苯苄唑乳膏治疗足癣(60例)进行疗效对比。结果“1+1”疗法组治愈率和有效率分别为84.62%和97.44%,而单一口服特比萘芬和单一外用联苯苄唑乳膏组治愈率和有效率分别为63.16%、63.33%和76.32%、76.66%。“1+1”疗法组与单一给药两组治愈率比较均有显著性差异(掊2=9.218,P=0.002;掊2=8.273,P=0.004),而单一给药两组间治愈率比较无显著性差异(掊2=0.000<0.01,P=0.983﹥0.05)。结论“1+1”疗法和单一口服药物疗法、单一外用药物疗法治疗足癣均有效,但以“1+1”疗法最佳。
Objective To investigate the effect of terbinafine plus bifenazole cream in treating tinea pedis with “1 + 1” therapy. Methods 78 cases of tinea pedis were treated with terbinafine plus bifenazole cream, and tinea pedis was treated with single oral terbinafine (76 cases) and single external bifenazole cream (60 cases ) For efficacy comparison. Results The cure rate and effective rate of the “1 + 1” therapy group were 84.62% and 97.44%, respectively, while the cure rates and effective rates of single oral terbinafine and single external use bifenazole cream group were 63.16% 63.33% and 76.32%, 76.66% respectively. There were significant differences in the cure rates between the “1 + 1” treatment group and the single administration group (掊 2 = 9.218, P = 0.002; 掊 2 = 8.273, P = 0.004) The cure rate was no significant difference (掊 2 = 0.000 <0.01, P = 0.983> 0.05). Conclusion “1 + 1 ” therapy and single oral drug therapy, single topical drug therapy for tinea pedis are effective, but to “1 + 1 ” the best therapy.