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目的探讨血小板α颗粒膜蛋白（GMP－140）及VonWillebrand因子（VWF）在小儿脑梗塞时的变化及其作用。方法采用ELISA法测定了34例脑梗塞患儿血浆GMP－140及VWF，并与20例对照组比较。结果脑梗塞患儿急性期血浆GMP－140及VWF明显高于对照组和恢复期；恢复期血浆GMP－140与对照组相比无显著性差异，而VWF仍高于对照组；双侧脑梗塞患儿血浆GMP－140及VWF含量明显高于单侧脑梗塞患儿。结论GMP－140及VWF参与了小儿脑梗塞的发病过程，且提示持续高水平的VWF可能是再次脑梗塞的潜在危险因素。
Objective To investigate the changes of platelet α-granule membrane protein (GMP-140) and Von Willebrand factor (VWF) in children with cerebral infarction. Methods The plasma levels of GMP-140 and VWF in 34 children with cerebral infarction were measured by ELISA and compared with 20 control subjects. Results The plasma levels of GMP-140 and VWF in children with acute cerebral infarction were significantly higher than those in control group and recovery period. There was no significant difference in plasma GMP-140 level between convalescent group and control group, while VWF was still higher than that in control group. Bilateral cerebral infarction Children with plasma GMP-140 and VWF levels were significantly higher than those in children with unilateral cerebral infarction. Conclusion GMP-140 and VWF are involved in the pathogenesis of childhood cerebral infarction, and suggest that continuous high-level VWF may be a potential risk factor for recurrent cerebral infarction.