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现代药学的迅速发展使得针对药物及其代谢物在机体内处置过程的研究不断深入。近年来,新颖液相色谱技术不断发展和完善,在灵敏度和选择性等方面都有了很大的提高,使得复杂生物样品中药物及其代谢物的测定变得更加准确、快速和简便。本文介绍近年来新型液相色谱技术在体内药物分析中的应用。 1 胶束色谱法(micellar chromatography,MC) MC是一种在常规色谱柱上实现体液样品直接进样分析的色谱方法。在荧光-液相色谱系统中使用十二烷基硫酸钠(SDS)和10%甲醇为流动相,直接进样可分析测定
The rapid development of modern pharmacy makes research on the disposal of drugs and their metabolites in the body continue to deepen. In recent years, the new liquid chromatography technology continues to develop and improve, in terms of sensitivity and selectivity have been greatly improved, making complex biological samples of the determination of the drug and its metabolites become more accurate, fast and easy. This article describes the application of new liquid chromatography in in vivo drug analysis in recent years. 1 micellar chromatography (MC) MC is a chromatographic method for performing direct injection analysis of body fluid samples on a conventional column. In the fluorescence - liquid chromatography system using sodium dodecyl sulfate (SDS) and 10% methanol as the mobile phase, direct injection can be analyzed and determined