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目的分析比较接受IVF-ET治疗的胚胎发育欠佳患者中,行卵裂期(D3)或囊胚期(D5或D6)移植,哪种方案更有利于改善临床妊娠结局。方法回顾性分析2014年2月—2016年1月于唐山市妇幼保健院接受IVF-ET治疗的胚胎发育欠佳夫妇278对,充分沟通后,根据其意向分为A组(卵裂期移植组)和B组(囊胚培养组),分析二组的妊娠率、种植率等。结果 A组与B组的移植周期临床妊娠率(31.0%vs 29.3%)、继续妊娠率(27.1%vs 25.9%)及种植率(19.6%vs 22.9%)差异均无统计学意义;取卵周期临床妊娠率A组显著高于B组(31.0%vs 13.8%),B组的周期取消率(52.8%)显著高于A组。结论发育欠佳胚胎在细胞期移植的临床结局优于继续囊胚培养,有利于提高临床妊娠率。
Objectives To compare which of the embryo developmentally dysplastic patients undergoing IVF-ET with cleavage (D3) or blastocyst stage (D5 or D6) is more favorable for improving clinical pregnancy outcomes. Methods A retrospective analysis of 278 couples with poor embryo development who underwent IVF-ET treatment in Tangshan MCH from February 2014 to January 2016 was conducted. After thorough communication, they were divided into group A (cleavage stage group ) And B group (blastocyst group), analysis of the two groups of pregnancy rate, planting rate and so on. Results The clinical pregnancy rate (31.0% vs 29.3%), continuous pregnancy rate (27.1% vs 25.9%) and implantation rate (19.6% vs 22.9%) in group A and group B had no significant difference Clinical pregnancy rate was significantly higher in group A than in group B (31.0% vs 13.8%), and in group B was significantly higher than that in group A (52.8%). Conclusion The clinical outcomes of poorly developed embryos in cell stage transplantation are better than those in continuing blastocyst culture, which is beneficial to improve the clinical pregnancy rate.