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目的观察快中子与光子混合射线治疗前列腺癌的效果及毒副作用。材料与方法北京市快中子治疗协作组于１９９２年１月～１９９６年６月共收治前列腺癌１９例。用快中子与光子混合射线治疗１６例，快中子剂量为６００～１１６０ｎｃＧｙ，Ｘ线剂量为３０００～６０００ｃＧｙ，前列腺局部剂量为６４８０～７８００ｃＧｙ。单纯快中子治疗组剂量１０００～１２００ｎｃＧｙ。中子治疗多用前后－后前（ＡＰ－ＰＡ）照射野，Ｘ线用４野“盒式”技术或５野照射盆腔。结果全组患者放疗后泌尿系统症状改善率９３．８％；８４．６％患者的卡氏行为状态评分（ＫＰＳ）值改进。全组７例死亡（５例死于本病，２例死于并发症）。２年生存率１０／１４（７１．４％），２年肿瘤专项生存率（ｃａｎｃｅｒ－ｓｐｅｃｉｆｉｃｓｕｒｖｉｖａｌ）１０／１２（８３．３％）；３年生存率６／７（８５．７％），３年肿瘤专项生存率６／６（１００．０％）。全组１３例（６８．４％）出现急性放射反应。长期生存患者１２例中，７例（５８．３％）出现晚期反应，３例（２５．０％）为Ⅰ～Ⅱ度，４例（３３．３％）Ⅲ～Ⅳ度。结论混合射线对前列腺癌有较好的疗效，但严重并发症发病率也较高。
Objective To observe the effect and toxicity of fast neutron and photon mixed radiation on prostate cancer. Materials and Methods Beijing fast neutron therapy cooperation group in January 1992 ~ June 1996 were treated 19 cases of prostate cancer. With fast neutron and photon mixed ray treatment of 16 cases, the fast neutron dose of 600 ~ 1160ncGy, X-ray dose of 3000 ~ 6000cGy, local prostate dose of 6480 ~ 7800cGy. Simple neutron therapy group dose 1000 ~ 1200ncGy. Neutron therapy before and after - before (AP-PA) radiation field, X-ray with 4 field “cassette” technology or 5 field irradiation pelvic. Results The improvement rate of urological symptoms in all the patients after radiotherapy was 93.8%. The Karnofsky Performance Score (KPS) value in 84.6% patients was improved. Seven patients died in the whole group (5 died of this disease and 2 died of complications). The 2-year survival rate was 10/14 (71.4%), 2-year cancer-specific survival 10/12 (83.3%), 3-year survival rate 6/7 (85.7%) 3 The annual tumor specific survival rate 6/6 (100.0%). The whole group of 13 patients (68.4%) showed acute radiation reaction. Among 12 patients with long-term survival, 7 patients (58.3%) had late response, 3 (25.0%) were grade Ⅰ ~ Ⅱ and 4 (33.3%) Ⅲ ~ Ⅳ. Conclusion Mixed rays have a good effect on prostate cancer, but the incidence of serious complications is also high.