论文部分内容阅读
目的:总结国内外关于Smad4在消化系统常见恶性肿瘤中研究进展。方法:应用PUBMED和CNKl期刊全文数据库检索系统,以“Smad4”和分别以“胰腺癌、食管癌、胃癌”等为关键词,检索1996-01-2009-01有关Smad4的文献205篇,其中英文文献160篇,中文文献45篇。纳入标准:1)Smad4的功能域、信号转导和调节;2)Smad4在消化系统常见恶性肿瘤中的表达情况;3)Smad4表达缺失与肿瘤进展相关性;4)以Smad4为靶点的肿瘤靶向研究。根据纳入标准,精选85篇文献,最后纳入分析25篇文献。结果:Smad4基因在胰腺癌,消化道腺癌中起着肿瘤抑制因子的作用,其表达缺失与这些肿瘤发生发展呈负相关,而在食管鳞癌中Smad4基因转录和其蛋白表达水平不一致且Smad4蛋白表达缺失与食管鳞癌的分级和分期的相关性研究文献较少。结论:深入研究Smad4在消化系统常见恶性肿瘤尤其是食管鳞癌中的表达及功能,有助于进一步理解肿瘤侵袭和转移的分子生物学机制,有望在肿瘤的靶向治疗方面取得新的突破。
Objective: To summarize the research progress of Smad4 in common malignant tumors of the digestive system at home and abroad. Methods: By using “PUBMED” and “CNKI” full-text database retrieval system, we searched “Smad4” and “pancreatic cancer, esophageal cancer, gastric cancer” as the key words to search the literature about Smad4 from January 1996 to January 2009-01 Articles, including 160 English articles and 45 Chinese articles. Inclusion criteria: 1) Smad4 domain, signal transduction and regulation; 2) Smad4 expression in common digestive system malignancies; 3) loss of Smad4 expression and tumor progression; 4) Targeted research. According to the inclusion criteria, 85 articles were selected and finally 25 articles were analyzed. Results: The Smad4 gene plays a role of tumor suppressor in pancreatic cancer and adenocarcinoma of the gut. The expression of Smad4 is negatively correlated with the occurrence and development of these tumors. However, Smad4 gene transcription and protein expression are not consistent in esophageal squamous cell carcinoma, and Smad4 There is little research on the correlation between protein expression loss and esophageal squamous cell carcinoma classification and staging. CONCLUSIONS: In-depth study of the expression and function of Smad4 in common malignant tumors of digestive system, esophageal squamous cell carcinoma in esophageal squamous cell carcinoma is helpful to further understand the molecular biology mechanism of tumor invasion and metastasis, and it is expected that new breakthrough will be made in the targeted therapy of tumor.