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本文采用均匀沉淀法,在室温条件下,合成了较为稳定的ZnO量子点。用荧光光谱法、紫外可见分光光度法分析了ZnO量子点与头孢哌酮的相互作用,用Stern-Volmer方程研究了头孢哌酮对ZnO量子点的荧光猝灭作用,结果表明属于静态荧光猝灭,计算了不同温度时的猝灭常数(292K:9.550×103 L·mol-1、303K:5.980×103 L·mol-1、313K:4.412×103 L·mol-1)和热力学参数,证明二者主要以范德华作用和氢键作用力结合。根据Forster的偶极-偶极非辐射能量转移原理计算出结合位置距离色氨酸残基2.47nm,发生分子内的非辐射能量转移。为探讨纳米颗粒与此类药物分子之间相互作用的化学机理提供了重要的信息。
In this paper, a uniform precipitation method, at room temperature, the synthesis of a more stable ZnO quantum dots. The interaction between ZnO quantum dots and cefoperazone was analyzed by fluorescence spectroscopy and ultraviolet-visible spectrophotometry. The fluorescence quenching of cefoperazone on ZnO quantum dots was studied by Stern-Volmer equation. The results showed that the fluorescence quenching , The quenching constants (292K: 9.550 × 103 L · mol-1,303K: 5.980 × 103 L · mol-1,313K: 4.412 × 103 L · mol-1) and the thermodynamic parameters were calculated at different temperatures. The main role of Van der Waals and hydrogen bonding force combination. According to Forster’s dipole-dipole non-radiative energy transfer principle, intramolecular non-radiative energy transfer takes place at a binding site of 2.47 nm from the tryptophan residue. Provide important information for exploring the chemical mechanism of the interaction between nanoparticles and such drug molecules.