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目的观察米非司酮联合米索前列醇药物流产后早期和延迟放置宫内节育器(IUD)的安全性和有效性。方法210例需行药物流产的妇女以1︰2比例随机分配到早期放置组和延迟放置组,早期组(74例)于药流后7~10 d放置IUD,延迟组(136例)于4~6周放置,术后随访半年并观察记录脱落、感染、出血等不良反应。结果两组IUD脱落率分别为5.5%和8.5%(P>0.05),因症取环率为10.9%和1.7%,早期组高于延迟组(P<0.05)。出血、疼痛和月经异常等不良反应两组接近,均未发生子宫穿孔、感染、带器妊娠。结论药物流产后早期放置IUD安全可靠,但最佳放置时间仍需进一步研究。
Objective To observe the safety and efficacy of mifepristone combined with misoprostol in the early and late post-abortion of IUD. Methods A total of 210 women undergoing medical abortion were randomized to early placement and delayed placement in a 1: 2 ratio. In the early group (74 patients), IUD was placed at 7 to 10 days after drug abortion, while in delayed group (136 patients) After 6 weeks of follow-up, six months of follow-up were observed and the adverse reactions such as exfoliation, infection and bleeding were observed. Results The IUD shedding rates in both groups were 5.5% and 8.5%, respectively (P> 0.05). The recovery rate of IUD was 10.9% and 1.7% respectively in the two groups. The early group was higher than the delayed group (P <0.05). Bleeding, pain and menstrual abnormalities and other adverse reactions close to the two groups, did not occur uterine perforation, infection, pregnancy with device. Conclusion It is safe and reliable to place IUD early after medical abortion, but the optimal placement time still needs further study.