论文部分内容阅读
目的对连续血液滤过联合甘露醇治疗颅内高压合并肾功能衰竭的疗效进行观察和分析。方法 36例颅内高压合并肾功能衰竭患者,随机分为观察组和对照组,各18例。两组患者均给予连续血液滤过治疗,观察组在此基础上联合甘露醇进行治疗。记录并比较两组治疗后患者颅内压、胱抑素浓度以及血肌酐浓度。结果治疗后,观察组患者的颅内压为(170.63±41.49)mm H_2O(1 mm H2O=0.0098 kPa),胱抑素浓度为(2.95±0.86)μmol/L,血肌酐浓度为(291.31±74.32)μmol/L;对照组患者的颅内压为(335.63±36.34)mm H_2O,胱抑素浓度为(5.68±1.19)μmol/L,血肌酐浓度为(587.43±66.89)μmol/L。观察组颅内压、胱抑素浓度、血肌酐浓度均明显低于对照组,差异均具有统计学意义(P<0.05)。结论连续血液滤过联合甘露醇应用于颅内高压合并肾功能衰竭的治疗中有显著效果,建议在临床上推广应用。
Objective To observe and analyze the curative effect of continuous hemofiltration and mannitol in patients with intracranial hypertension combined with renal failure. Methods 36 patients with intracranial hypertension complicated with renal failure were randomly divided into observation group and control group, with 18 cases in each group. Two groups of patients were given continuous hemodialysis treatment, the observation group on this basis combined with mannitol for treatment. Record and compare intracranial pressure, cystatin concentration and serum creatinine concentration after treatment in both groups. Results After treatment, the intracranial pressure in the observation group was (170.63 ± 41.49) mm H 2 O (1 mm H 2 O = 0.0098 kPa), the cystatin concentration was (2.95 ± 0.86) μmol / L and the serum creatinine concentration was (291.31 ± 74.32) ) in the control group was (335.63 ± 36.34) mm H 2 O, cystatin was (5.68 ± 1.19) μmol / L, and serum creatinine was (587.43 ± 66.89) μmol / L in the control group. The intracranial pressure, cystatin and serum creatinine in observation group were significantly lower than those in control group (P <0.05). Conclusion Continuous hemofiltration combined with mannitol in the treatment of intracranial hypertension combined with renal failure have a significant effect, it is recommended to promote the clinical application.