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目的:观察阿卡波糖对急性脑出血继发高血糖患者的预后影响。方法:120例急性脑出血患者随机分为治疗组59例和对照组61例。对照组采用脱水、降颅压、营养神经等方法综合治疗脑出血,治疗组在此基础上予阿卡波糖50 mg,餐时口服或鼻饲,tid。疗程均为8周。观察两组治疗前后空腹血糖(FBG)及餐后2 h血糖(2hPG)、糖化血红蛋白(HbA1c)、三酰甘油(TG)、总胆固醇(TC)等指标的变化。并比较两组疗效。结果:两组治疗前FBG、2hPG及神经功能缺损程度评分均无差异(P>0.05)。治疗后两组FBG、2hPG、HbA1c及血脂有显著差异(P<0.05),神经功能缺损程度评分比较亦有显著差异(P<0.05)。治疗组总有效率91.53%,明显高于对照组的72.13%(P<0.05)。结论:急性脑出血继发高血糖患者早期口服阿卡波糖能明显改善神经功能缺损程度,提高生活质量。
Objective: To observe the effect of acarbose on the prognosis of patients with hyperglycemia secondary to acute intracerebral hemorrhage. Methods: A total of 120 patients with acute cerebral hemorrhage were randomly divided into treatment group (n = 59) and control group (n = 61). Control group using dehydration, intracranial pressure, nutritional nerves and other methods of comprehensive treatment of intracerebral hemorrhage, the treatment group on the basis of acarbose 50 mg, mealtime oral or nasogastric, tid. The course of treatment is 8 weeks. The changes of fasting blood glucose (FBG) and postprandial 2h blood glucose (2hPG), HbA1c, triglyceride (TG) and total cholesterol (TC) were observed before and after treatment. And compare the two groups curative effect. Results: There was no difference in FBG, 2hPG and neurological deficit score between the two groups before treatment (P> 0.05). After treatment, the FBG, 2hPG, HbA1c and blood lipid in the two groups were significantly different (P <0.05), and the scores of neurological deficits were also significantly different (P <0.05). The total effective rate was 91.53% in the treatment group, which was significantly higher than that in the control group (72.13%, P <0.05). Conclusion: Early oral acarbose in patients with hyperglycemia secondary to acute intracerebral hemorrhage can significantly improve the degree of neurological deficits and improve the quality of life.