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目的 探讨ｐ５３ 改变在胃癌发生发展中是早期抑或是晚期事件，ｐ５３ 改变与一些不良预后关系。方法 对正常胃粘膜、各种胃癌前病变及胃癌（早期和进展期）进行ｐ５３ 免疫组化染色。结果 ｐ５３ 阳性率为正常胃粘膜０％ （０／１７），胃腺瘤６０％ （３／５），肠上皮化生１１．５４％ （３／２６），轻中重度不典型增生分别为５％ （１／２０）、２５％ （３／１２）、５７．８４％ （１１／１９），早期胃癌４４．４４％ （４／９），进展期胃癌６２．７１％ （３７／５９），高中低未分化腺癌分别是７１．４３（５／７），６３．１６％ （１２／１９）、６０．６１％ ，（４／９），有和无淋巴结转移的胃癌６５％ （７／１３）、６７．５７（２５／３７）。统计学分析表明肠上皮化生与早期胃癌，轻中度不典型增生与重度不典型增生之间有统计学差异（Ｐ＜ ０．００５），腺瘤、重度不典型增生、早期与进展期胃癌之间，细胞学分级，有无淋巴结转移间无统计学差异（Ｐ＞ ０．０５，Ｐ＞ ０．５，Ｐ＞ ０．５）。结论 ｐ５３ 改变在胃癌的发生中是一个早期事件，对早期诊断形态上难以鉴别的重度不典型增生和胃癌有重要的辅助诊断作用，ｐ５３改变在胃癌由早期向晚期发展的过程中稳定性加强，但与?
Objective To investigate whether p53 alterations are early or late events in the development of gastric cancer, and the relationship between p53 changes and some poor prognosis. Methods p53 immunohistochemical staining was performed on normal gastric mucosa, various gastric precancerous lesions, and gastric cancer (early and advanced stages). Results The positive rate of p53 was 0% (0/17) in normal gastric mucosa, 60% (3/5) in gastric adenoma, 11.54% (3/26) in intestinal metaplasia, and 5% in moderate-to-severe dysplasia. (1/20), 25% (3/12), 57.84% (11/19), 44.44% (4/9) of early gastric cancer, 62.71% (37/59) of advanced gastric cancer, and high school Low undifferentiated adenocarcinomas were 71.43 (5/7), 63.16% (12/19), 60.61%, (4/9), and 65% of gastric cancers with and without lymph node metastasis (7/13) ), 67.57 (25/37). Statistical analysis showed a significant difference between mild to moderate dysplasia and severe dysplasia in intestinal metaplasia and early gastric cancer (P < 0.005), adenoma, severe dysplasia, early and advanced gastric cancer There was no statistical difference between cytological grading and lymph node metastasis (P> 0.05, P> 0.5, P> 0.5). Conclusions The p53 alteration is an early event in the development of gastric cancer. It plays an important role in the early diagnosis of severe dysplasia and gastric cancer, which is difficult to identify morphologically. The p53 changes in the stability of gastric cancer from the early stage to the late stage. But with?