【摘 要】
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Ferroptosis is an iron-dependent form of cell death character-ized by an accumulation of lipid peroxides.A growing body of recent evidence supports the notion that ferroptosis plays an important role in mediating a wide variety of cellular processes in di
【机 构】
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The First Affiliated Hospital,School of Public Health,Institute of Translational Medicine,Zhejiang U
论文部分内容阅读
Ferroptosis is an iron-dependent form of cell death character-ized by an accumulation of lipid peroxides.A growing body of recent evidence supports the notion that ferroptosis plays an important role in mediating a wide variety of cellular processes in diseases.Notably,ferroptosis can play a significant role in medi-ating various functions in immune cells and immunotherapies.Here,we discuss our current understanding regarding the regula-tory role of ferroptosis in immune cells,including T cells,B cells,granulocytes,monocytes,and macrophages.In addition,we dis-cuss the general effect of immune cell ferroptosis on human patho-physiology and immunotherapies,thereby suggesting new strategies for targeting ferroptosis in order to modulate the immune system and unravel the mechanisms that underlie ferrop-tosis in the immune response.
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