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目的 分析 1997年 3月至 1999年 3月北京地区儿童急性下呼吸道感染 (ALRI)的病毒病因。方法 对因ALRI住院患儿 ,取鼻咽分泌物做免疫荧光检测筛查 7种呼吸道病毒抗原 ,阳性病例入选 ,分析其病历资料。结果 所有 794例患儿送检标本共 796份 ,阳性 2 2 8份 (2 8 6 % )。其中资料完整的阳性病历共 2 0 3例 ,男性 144例 ,女性 5 9例。 2 0 3例中呼吸道合胞病毒 (RSV)最多 ,共 179例 (88 2 % ) ,其次为流感病毒A(IA)型 19例 (9 4% ) ,腺病毒 (ADV) 3例 (1 4% ) ,副流感病毒 3型 (PIV3) 2例 (0 98% )。RSV和IA感染呈季节性分布。 76例患儿(37 4% )有并发症。小年龄组病情明显重于大年龄儿 ,<2个月需要吸氧者明显多于≥ 2个月的患儿 (88 9%对74% ,P <0 0 5 )。结论 北京地区两年来ALRI患儿的病毒学病因为RSV、IA、ADV和PIV3,以RSV为主 ,并有一定的季节变化
Objective To analyze the viral etiology of childhood acute lower respiratory tract infection (ALRI) in Beijing from March 1997 to March 1999. Methods A total of 7 respiratory virus antigens were screened by immunofluorescence in children with ALRI hospitalization and nasopharyngeal secretions. The positive cases were selected and their medical records were analyzed. Results A total of 796 samples of all 794 children were tested, with a positive rate of 228 (2.86%). There were 203 positive cases with complete information, including 144 males and 59 females. There were 179 cases (88.2%) of respiratory syncytial virus (RSV) in 203 cases, 19 cases (94%) of influenza A (IA), 3 cases of adenovirus (ADV) %), 2 cases of parainfluenza virus type 3 (PIV3) (0 98%). RSV and IA infections are seasonal. 76 patients (37 4%) had complications. Patients in the younger age group were significantly more likely to be older than those in the older age group, with <2 months requiring significantly more oxygen for more than 2 months (88.9% vs. 74%, P <0 05). Conclusions The virological causes of ALRI children in Beijing in the past two years are RSV, IA, ADV and PIV3, with RSV as the predominant and have some seasonal changes