GNB3基因C825T位多态性与高血压患者发生心脑血管事件相关性研究进展

• 作 者: 朱玮玮 华琦
• 机 构: 首都医科大学宣武医院心脏科,
• 出 处: 慢性病学杂志
• 发表日期: 2015年06期
• 关键词: C825T GNB3 心脑血管 G蛋白 基因多态性 高血压 心血管事件 多态性 心脑血管疾病 等位基因

心脑血管事件是东方国家死亡的首要原因,已经成为世界关注的健康问题。另外,高血压是心血管疾病中发生率最高的疾病,在其发生中起重要作用。研究表明GNB3基因C825T多态性与高血压、肥胖、糖尿病有关。而这些都是心脑血管疾病的危险因素,它们可能有共同的遗传特点。因此,研究此基因多态性在心血管事件和高血压发生、发展中的作用意义重大。

Cardiovascular and cerebrovascular events are the leading cause of death in the Eastern countries and have become a health issue of concern to the world. In addition, hypertension is the most frequently occurring disease in cardiovascular disease and plays an important role in its development. Studies have shown that GNB3 gene C825T polymorphism and hypertension, obesity, diabetes. And these are risk factors for cardiovascular and cerebrovascular diseases, they may share a common genetic characteristics. Therefore, to study the genetic polymorphisms in the occurrence and development of cardiovascular events and hypertension is of great significance.