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在发展新的抗肿瘤化合物中,发现了具有低毒与特异性抗肿瘤谱的新型化合物,并合成了约800种氨基酸衍生物。在这些化合物的试验中,发现乙基脲甲基-L-丝氨酸(A-748)对AH-41C、AH-66和AH-60C腹水肝细胞瘤有较强的抗肿瘤作用,对实体肿瘤艾氏癌和肉瘤180也有明显的抗肿瘤作用。尤其对大白鼠的腹水肝细胞瘤具有特异的抗肿瘤作用。一村(Ichimura)报道了在这些肝细胞瘤中AH-60C显示了对所有抗肿瘤药物的完全抗药性,AH-41C对除了甲基苄肼外的抗肿瘤药物反应不敏感。一村氏指出具有抗AH-
In the development of new antitumor compounds, novel compounds with low toxicity and specific antitumor spectrum were found and about 800 amino acid derivatives were synthesized. In the tests of these compounds, it was found that ethylurea methyl-L-serine (A-748) has a strong anti-tumor effect on AH-41C, AH-66 and AH-60C ascites hepatoma cells, Cancer and sarcoma 180 also have significant anti-tumor effects. Especially for rat ascites hepatoma has a specific antitumor effect. Ichimura reported that AH-60C showed complete resistance to all antineoplastic agents in these hepatoma cells, and that AH-41C was insensitive to antineoplastic agents other than procarbazine. One village pointed out that with anti-AH-