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目的 :对河北省恙虫病疫源地内病例进行血清学分型和抗体动态观察 ,了解疫源地和非疫源地内人群恙虫病抗体阳性率 ,初步掌握恙虫病血清流行病学规律。方法 :采集患者病后不同时期的血清标本和疫源地内及非疫源地内人群血清标本 ,用间接免疫荧光法检测恙虫病抗体。结果 :2 7例恙虫病患者均被证实为Gilliam血清型。病后第 3d即可出现IgM和IgG抗体 ,2 0d至 1年IgM和IgG抗体阳性率均为 10 0 % ,抗体滴度高峰为病后 10～ 19d ,之后开始逐渐下降。疫源地内健康人群IgG和IgM抗体阳性率分别为7.70 %和 4.81% ,提示可能存在隐性感染。非疫源地内未发现抗体阳性者。结论 :初步阐明恙虫病的血清流行病学特点。在流行区可能存在隐性感染
OBJECTIVE: To investigate the serological typing and antibody dynamic in cases of tsutsugamushi disease in Hebei Province, and to know the positive rate of antibodies against tsutsugamushi in crowd and non-epidemic areas and to master the epidemiological rules of tsutsugamushi disease. Methods: Serum samples were collected from patients at different stages of illness and from the population of non-epidemic foci, and antibodies against scrub typhus were detected by indirect immunofluorescence assay. Results: Twenty-seven tsutsugamushi patients were confirmed as Gilliam serotypes. The IgM and IgG antibodies appeared on the 3rd day after the illness. The positive rates of IgM and IgG antibodies on the 20th day to 1 year were all 10%. The peak of the antibody titers was 10-19 days after the disease, and then gradually decreased. The positive rates of IgG and IgM antibodies in healthy population were 7.70% and 4.81%, respectively, suggesting that there may be latent infection. Antibody-positive persons were found in non-epidemic areas. Conclusion: Preliminary elucidation of the epidemiological characteristics of scrub typhus. In endemic areas there may be a latent infection