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目的对河南省沈丘县人群多环芳烃(PAHs)暴露水平进行生物监测,评价PAHs暴露与消化道癌症的关联性。方法采用病例对照研究方法,分别募集自河南省沈丘县肿瘤高聚集区和低聚集区的41例食管癌、26例胃癌、17例肝癌患者和19例健康对照,采用固相萃取-超高效液相色谱-串联质谱法检测血中3种致癌性多环芳烃苯并(a)芘(BaP)、苯并(g,h,i)苝[B(g,h,i)P]、二苯并(a,h)蒽[DB(a,h)A]暴露水平和尿中2-羟基萘(2-OHN)、2-羟基芴(2-OHF)、1-羟基芘(1-OHP)3种羟基多环芳烃代谢水平,用SPSS17.0进行数据分析。结果 66.9%的研究对象尿中1-OHP高于一般居民生物暴露限值(0.11μmol/mol Cr)。肿瘤高聚集区和低聚集区人群间多环芳烃暴露水平差异无统计学意义(P>0.05);高、低聚集区病例组血中B(g,h,i)P暴露水平均高于对照组,差异具有统计学意义(P<0.05)。随着体内B(g,h,i)P暴露水平的增加,消化道癌症的发病风险增加。结论该地区研究人群的PAHs暴露水平普遍较高,食管癌、胃癌及肝癌的发病可能与某些致癌性多环芳烃的暴露有关,需要进一步研究进行证实。
Objective To monitor the level of PAHs in Shenqiu County of Henan Province and evaluate the correlation between PAHs exposure and gastrointestinal cancer. Methods A case-control study was conducted in 41 cases of esophageal cancer, 26 cases of gastric cancer, 17 cases of hepatocellular carcinoma and 19 healthy controls from high-concentration and low-concentration areas in Shenqiu County of Henan Province. (A, b), B (g, h, i) P] in blood were determined by liquid chromatography-tandem mass spectrometry Exposure of benzo (a, h) anthracene [DB (a, h) A] to urinary 2-hydroxynaphthalene (2-OHF), 1-OHP ) Three kinds of hydroxy PAH metabolism, using SPSS17.0 for data analysis. Results The urinary 1-OHP in 66.9% of the subjects was higher than that of the general population (0.11μmol / mol Cr). There were no significant differences in the levels of polycyclic aromatic hydrocarbons (PAHs) exposure between the high and low aggregation areas (P> 0.05). The levels of B (g, h, i) P in the high and low aggregation areas were higher than those in the control Group, the difference was statistically significant (P <0.05). As the level of B (g, h, i) P exposure increases, the risk of gastrointestinal cancers increases. Conclusions The population of PAHs in the study population is generally high. The incidence of esophageal cancer, gastric cancer and hepatocellular carcinoma may be related to the exposure of some carcinogenic PAHs, which needs further study to confirm.