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目的观察乌司他丁对全氟异丁烯吸入性急性肺损伤的防治效果。方法 采用小鼠全氟异丁烯全身暴露动态染毒系统对实验小鼠进行染毒,观察不同剂量的乌司他丁于全氟异丁烯暴露后不同时间尾静脉注射给药的存活率、肺系数(湿肺体比、干肺体比、肺含水量、肺湿干比)。结果在全氟异丁烯暴露后不同时间(1、2、4、8h)经尾静脉注射给药不同剂量乌司他丁(40万、80万U/kg),除于暴露后4和8h乌司他丁40万U/kg组观察到湿肺体比和肺湿干比给药组较对照组明显下降(P均<0.05)外,不论是肺系数还是中毒小鼠存活率观察,均未观察到乌司他丁对全氟异丁烯染毒小鼠明显的治疗作用(P均>0.05)。结论在本项研究的实验条件下,未观察到乌司他丁对全氟异丁烯吸入性急性肺损伤具有治疗作用。
Objective To observe the prevention and treatment of ulinastatin on perfluoroisobutylene inhalation induced acute lung injury. Methods The mice were exposed to perfluorobutyrate (DBP) system by dynamic exposure system. The survival rates of ulinastatin at different dosages after tail vein injection of perfluoroisobutylene were observed. The pulmonary coefficient Lung ratio, dry lung ratio, lung moisture, lung wet ratio). Results Different dosages of ulinastatin (400,000, 800,000 U / kg) were administered via caudal vein injection at different times (1, 2, 4 and 8 hours) after exposure to perfluoroisobutylene. Except for 4 and 8 hours after exposure, In the 40 mg U / kg group, the wet lung ratio and lung wet / dry ratio were significantly decreased compared with the control group (all P <0.05), and neither the lung coefficient nor the survival rate of the poisoned mice was observed The effect of ulinastatin on perfluoroisobutylene-treated mice was significant (all P> 0.05). Conclusions Ulinastatin has no therapeutic effect on perfluoroisobutylene-induced acute lung injury under the experimental conditions in this study.