妇女胆石症与雌激素有关

• 作 者: 彭力宏
• 机 构: 河南武警总队医院药房,
• 出 处: 中原医刊
• 发表日期: 1986年05期
• 关键词: 胆囊收缩 青春期前 胆固醇浓度 胆固醇结石 口服避孕药 去氢胆酸 性别差异 性比 月经周期

西德的一位医生在对男、女青春期前后胆固醇浓度进行研究后,发现女性随着青春期的到来,胆固醇浓度急剧上升。长期以来发现,女性比男性更容易患胆石症,这种性别差异,在青春期早期即已开始。对女性胆囊内胆固醇结石的发病率较高,曾有几种可能的解释,包括胆囊收缩较慢和女性倾向于发胖等。近来发现,接受口服避孕药的妇女更易发生胆石症。这提示雌激素会起一定作用,可能是高激素水平提高了胆汁的浓度,后者又促进了胆石的形成。

After a study of cholesterol concentrations in both men and women before and after puberty, a West German doctor found that women had a sharp increase in cholesterol levels with adolescence. It has long been found that women are more susceptible to cholelithiasis than men and this gender difference has already begun in early adolescence. There are several possible explanations for the high prevalence of cholesterol gallstones in women’s gallbladder, including slow gallbladder contraction and women’s tendency to gain weight. Recently found that women receiving oral contraceptives more prone to cholelithiasis. This suggests that estrogen may play a role, probably because high hormone levels increase bile concentrations, which in turn promote gallstone formation.