论文部分内容阅读
在免疫缺陷与常染色体的异常之间,认为有二种肯定的联系。一些共济失调毛细血管扩张症病人显示普遍的染色体不稳定性,有许多自发断裂,特别是14号染色体及其它D群染色体。IgA缺乏有时伴有18号染色体的异常如短臂和长臂缺失、环状和大染色体。作者报告4例有特殊面容的免疫缺陷儿童,其染色体各有一种异常。按抗体免疫缺陷,不仅研究了PHA刺激的T淋巴细胞的染色体,而且作了PWM(商陆丝裂素)刺激的B细胞的染色体。
There are two affirmative links between immunodeficiency and autosomal abnormalities. Some patients with ataxia telangiectasia show a generalized chromosomal instability with many spontaneous ruptures, especially chromosome 14 and other D-chromosomes. IgA deficiency is sometimes accompanied by abnormalities on chromosome 18 such as short and long arm deletions, circular and large chromosomes. The authors report 4 cases of immunodeficiency children with a special face, the chromosomes have an exception. According to antibody immunodeficiency, not only the chromosomes of PHA-stimulated T lymphocytes were studied but also the chromosomes of B cells stimulated by PWM (mitochondria).