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目的 目前肿瘤治疗包括手术治疗、化疗、放疗等,但并不能收到令人满意的效果,因此探究新的治疗方案迫在眉睫.如今,肿瘤靶向治疗已成为最具前途的一种新型治疗手段.越来越多的证据显示,Notch信号通路在各种恶性肿瘤的病理生理中发挥着重要作用.在肿瘤靶向治疗中Notch信号通路抑制剂的应用目前处于起步阶段.该文对目前研究的Notch信号通路在各种肿瘤中的关键机制、新数据以及Notch信号通路靶向治疗最新进展予以综述.“,”Cancer was the leading cause of death in humans and the incidence of tumor increased year by year.Despite advances in surgery,chemotherapy,and radiotherapy,we still cant get a satisfactory result.Novel therapeutic strategies are desperately needed.Nowadays,cancer targeted therapy has become the most promising treatment.There is some evidence demonstrating that the Notch signaling pathway is critically involved in the pathobiology of a variety of malignancies.Notch signal pathway inhibitors in tumor targeting therapy applied was currently in its infancy.In this review,we study the key mechanism and new data of Notch signaling pathway in various tumor,summarized the latest progress of Notch signaling pathway targeted therapy.