【摘 要】
：
Objective: Through observing the clinical response to neoadjuvant intraarterial chemotherapy in locally advanced cervical cancer and investigating the changes o
【机 构】
：
Department of Gynecology,Department of Pathology
论文部分内容阅读
Objective: Through observing the clinical response to neoadjuvant intraarterial chemotherapy in locally advanced cervical cancer and investigating the changes of p53 protein expression, proliferation and apoptosis of tumor cells after chemotherapy, to study the relationship between biological markers and chemotherapeutic response. Methods: 20 women with locally advanced squamous cervical cancer received consecutive infusion chemotherapy of five days of cisplatin and adriamycin via the superselective uterine artery. The response to chemotherapy was evaluated by gynecologic examination and ultrasonography 3 weeks after chemotherapy. The changes of apoptotic index (AI), proliferation index (PI) and p53 expression of tumor cells were detected by immunohistochemical technique. Results: The clinical response rate of locally advanced squamous cervical cancer to uterine artery infusion chemotherapy was 70%. No change of PI was found 3 weeks after treatment, but AI significantly increased from 2.79±0.76 to 4.29±1.13 (P
其他文献
目的寻找精确反映蚯蚓提取物中蛋白质含量的测定方法.方法采用改良Lowry法和考马斯亮蓝染料结合法(Bradford法)测定蚯蚓提取物蛋白质含量;再使用两法测定标准牛血清白蛋白(BS
禽流感(avian influenza)是由A型流感病毒引起禽类的一种从呼吸系统感染到败血症等多种症状的传染病[1],主要发生在鸡、鸭、鹅、鸽等禽类动物中.禽流感自1878年首次发生于意
通过断口宏观分析、金相组织检查、硬度测试及化学成分分析,对某发动机喷油器压板螺栓的断裂原因进行分析。结果表明,螺栓硬度不符合相关要求及螺纹表面存在微裂纹是该螺栓断
在前期焊接试验参数优化基础上,对TC4+TC17钛合金进行线性摩擦焊,焊后进行不同温度的热处理,并利用光学显微镜、扫描电镜等对不同状态接头组织进行对比分析。结果表明,焊态下
目的 研究调节过程中眼散光的变化趋势.方法 前瞻性病例对照研究.对2011年4～7月间在天津眼科医院就诊病人中应用开放视野式红外线自动验光仪测量不同调节刺激时球镜和柱镜的变
经调查,西藏色季拉山东坡野果有较为丰富的资源量,具有种类多、种间差异大和采收期长等特点。由于该地区经济、交通相对落后,所有野果资源未得到有效利用。通过系统的调查,初
颈动脉狭窄动物模型制备的方法很多,包括颈动脉外膜植入硅橡胶圈法、球囊损伤法、电刺激法、空气造模法及外科手术线扎法等,但是不同模型的颈动脉狭窄形成的机制及病理各有其
Objective To investigate the role of anti- interleukin-2 receptor(CD25) monoclonal antibody in the regulation of cytokine mRNA expression of IL-1β, IL-2, CD25,
Objective To evaluate the ability of a risk of malignancy index (RMI), based on serum CA125 level, ultrasound findings and menopausal status, to discriminate b
Objective To anatomically reconstruct the oculomotor nerve, trochlear nerve, and abducent nerve by skull base surgery. Methods Seventeen cranial nerves (three o