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目的探讨人绒毛膜促性腺激素(HCG)和促卵泡激素(FSH)联合治疗男性低促性腺激素性性腺功能减退症的有效性和安全性。方法29例男性低促性腺激素性性腺功能减退症23例,Kallmann综合征6例。治疗方案:采用联合HCG 2000 IU,2次/周;FSH 75 IU,3次/周,肌肉注射,连续用药至少3个月。结果治疗后所有患者体力改善,体质增强;22例患者出现胡须、阴毛和(或)腋毛。睾丸体积治疗前(2.68±1.44)ml,治疗后(8.93±3.24)ml(P<0.01);促卵泡激素(FSH)、促黄体激素(LH)和睾酮(T)水平有所提高(P<0.05);12例患者出现遗精现象,8例有精子生成。结论对男性低促性腺激素性性腺功能减退症,用HCG和FSH治疗能促进青春期第二性征发育,并可使部分睾丸恢复产生雄激素和生成精子功能。
Objective To investigate the efficacy and safety of combination of human chorionic gonadotropin (HCG) and follicle stimulating hormone (FSH) in the treatment of hypogonadotropic hypogonadism in men. Methods Twenty-nine male patients with hypogonadotropic hypogonadism in 23 cases and Kallmann’s syndrome in 6 cases. Treatment options: Combined HCG 2000 IU, 2 times / week; FSH 75 IU, 3 times / week, intramuscular injection, continuous medication for at least 3 months. Results All patients improved physical strength and physical fitness after treatment. Twenty-two patients had beard, pubic hair and / or armpit hair. The testicular volume increased (2.68 ± 1.44) ml and after treatment (8.93 ± 3.24) ml (P <0.01), while the levels of follicle stimulating hormone (FSH), luteinizing hormone (LH) and testosterone (T) 0.05); 12 patients showed spermatorrhea, 8 cases of spermatogenesis. Conclusions For male patients with hypogonadotropic hypogonadism, treatment with HCG and FSH can promote the development of second sexual characteristics during adolescence and restore some androgen production and sperm production in some testes.