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目的:通过检测不同类型子宫肌瘤手术患者血清肿瘤标记物CA125含量,探讨CA125在子宫肌瘤患者诊断和术后随访中的作用。方法:选取江苏通州人民医院妇科2010年1月至2014年12月间施行手术的子宫肌瘤患者137例作为研究对象,收集研究对象手术前血清标本,运用ELISA法检测血清CA125含量;术中行病理检测。结果:子宫肌瘤合并腺肌症患者和子宫肌瘤直径≥5 cm患者的CA125含量明显高于单纯子宫肌瘤患者;多变量分析结果显示子宫肌瘤合并腺肌症患者(OR=7.7,95%CI 2.6~23.0,P<0.001);子宫肌瘤直径大于等于5 cm患者(OR=5.6,95%CI1.4~22.8,P=0.016)。结论:血清CA125异常增高可作为在子宫肌瘤病变程度的独立预测因子,其表达水平与子宫肌瘤患者病情复杂程度密切相关,我们推测腹膜刺激可能是CA125升高的可能原因。
Objective: To investigate the role of CA125 in the diagnosis and postoperative follow-up of patients with uterine fibroids by detecting the serum tumor marker CA125 levels in patients with different types of uterine fibroids. Methods: Thirteen 137 patients with uterine fibroids underwent surgery from January 2010 to December 2014 in Gynecological Department of Tongzhou People’s Hospital of Jiangsu Province were enrolled. Serum samples were collected before operation and serum CA125 levels were measured by ELISA. Detection. Results: The CA125 level in patients with uterine fibroids complicated with adenomyosis and uterine fibroids was significantly higher than that in patients with simple uterine fibroids. Multivariate analysis showed that patients with uterine fibroids complicated with adenomyosis (OR = 7.7, 95 % CI 2.6 ~ 23.0, P <0.001); patients with uterine fibroids larger than 5 cm in diameter (OR = 5.6,95% CI 1.4-22.8, P = 0.016). CONCLUSIONS: The abnormal serum CA125 level may be an independent predictor of the degree of uterine leiomyoma. The expression of CA125 is closely related to the complexity of uterine leiomyoma patients. We speculate that peritoneal stimulation may be the possible cause of CA125 elevation.