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近年来对皮质激素(下称激素)类软膏疗效评价的方法很多,并提高了产品疗效,减轻了快速耐受性。提高激素类软膏疗效的方法主要有:(1)将激素制成溶解性软膏,常用溶煤有丙二醇、二甲基亚砜,或二者合用。药物完全溶解时,则释放药物快;溶解的药物其浓度近于饱和时释放率最大,对皮肤的穿透率亦最大。根据这一理论,用无水无油乳剂基质、凝胶基
In recent years, there are many ways to evaluate the curative effect of cortical hormone (hereinafter referred to as hormone) ointment, and improve the curative effect of the product and reduce the rapid tolerance. The main methods to improve the efficacy of hormone ointment are: (1) the hormone made of ointment dissolved, commonly used dissolved coal with propylene glycol, dimethyl sulfoxide, or a combination of the two. When the drug is completely dissolved, the drug is released quickly; the dissolved drug has the highest release rate near saturation and the highest skin penetration rate. According to this theory, use anhydrous oil-free emulsion base, gel-based