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目的研究强化胰岛素治疗危重症患者应激性高血糖的临床效果。方法 114例危重症应激性高血糖患者,采取数字随机法分成观察组和对照组,每组57例。对照组采取胰岛素治疗,观察组采取强化胰岛素治疗。比较两组临床效果。结果观察组抗生素使用时间为(12.9±2.4)d、呼吸机使用时间为(9.3±3.7)d、住院时间为(14.9±3.1)d、胰岛素使用量为(50.3±12.3)U、ICU入住时间为(9.8±3.7)d,均优于对照组的(15.1±3.0)d、(12.1±4.4)d、(16.9±3.4)d、(59.6±11.1)U、(16.7±4.6)d,差异均有统计学意义(P<0.05)。观察组低血糖发生率为3.51%、院内感染率为5.26%、死亡率为7.02%,均低于对照组的15.79%、22.81%、21.05%,差异均有统计学意义(P<0.05)。结论强化胰岛素治疗危重症患者应激性高血糖的临床效果显著,并且应用安全,是一种有效的治疗方法。
Objective To study the clinical effect of intensive insulin therapy on stress hyperglycemia in critically ill patients. Methods A total of 114 critically ill patients with stress hyperglycemia were divided into observation group and control group by digital randomization method, with 57 cases in each group. The control group took insulin therapy and the observation group took intensive insulin therapy. The clinical effects of two groups were compared. Results The use of antibiotics in the observation group was (12.9 ± 2.4) d, the duration of ventilator use was (9.3 ± 3.7) days, the length of hospital stay was (14.9 ± 3.1) days, the amount of insulin used was (50.3 ± 12.3) (9.8 ± 3.7) d, (15.1 ± 3.0) d, (12.1 ± 4.4) d, (16.9 ± 3.4) d, (59.6 ± 11.1) U and (16.7 ± 4.6) d respectively in the control group All were statistically significant (P <0.05). The incidence of hypoglycemia in observation group was 3.51%, the infection rate in hospital was 5.26% and the mortality rate was 7.02%, which were all lower than those in control group (15.79%, 22.81%, 21.05%). The difference was statistically significant (P <0.05). Conclusion The clinical effect of intensive insulin therapy on critically ill patients with stress hyperglycemia is significant and safe to use. It is an effective treatment.