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动态观察实验性感染华支睾吸虫豚鼠肝脏病理变化的结果表明,光镜下,感染后2周始,汇管部胆管上皮脱落,渐呈乳头状增生,管壁周围纤维组织增殖且不断向小叶内伸展和大量炎性细胞浸润。肝细胞呈水样变性和局灶性坏死。7周后,胆管上皮腺瘤样组织和小胆管增生明显,胆管多显著扩张。肝细胞索解离,有空泡变性和溶解坏死。透射电镜下发现,感染早期,肝细胞核和一些膜性细胞器出现轻度病变,6周后,粗面内质网扩张成池,线粒体基质透明、空泡化。组织化学观察结果,示肝细胞内糖原、蛋白质、RNA减少或消失,胞质内出现脂肪滴,SDH、MAO活性呈渐进性减少。7周后,不断增殖的胆管和增生的小胆管处,糖原、RNA、粘蛋白含量明显增加,AKP、ACP有处呈强阳性。
Dynamic observation of experimental pathological changes of guinea pigs infected with C. sinensis guinea pig liver pathological changes showed that, under light microscope, 2 weeks after infection, Department of bile duct epithelial shedding, gradually papillary hyperplasia, proliferation of fibrous tissue around the wall and continue to the leaflets Internal stretch and a large number of inflammatory cell infiltration. Liver cells were watery degeneration and focal necrosis. After 7 weeks, hyperplasia of cholangioendothelioma-like tissue and small bile ducts was obvious, and the bile ducts were significantly expanded. Liver cell cord dissociation, vacuolar degeneration and dissolved necrosis. Transmission electron microscopy showed that in the early stage of infection, hepatocyte nuclei and some membranous organelles appeared mild lesions. After 6 weeks, the rough endoplasmic reticulum expanded into a pool, the mitochondrial matrix was transparent and vacuolated. Histochemistry showed that glycogen, protein and RNA in hepatocytes decreased or disappeared, lipid droplets appeared in the cytoplasm, and the activities of SDH and MAO decreased gradually. Seven weeks later, the proliferation of bile ducts and hyperplastic small bile duct, glycogen, RNA, mucin content was significantly increased, AKP, ACP there was strongly positive.