论文部分内容阅读
神经病理性疼痛(NP)是最常见的一种慢性疼痛,其特点为持续的自发痛、异常疼痛和痛觉过敏.神经病理性疼痛在普通人群的发病率为7％～10％,其发病机制复杂,涉及周围及中枢神经系统.患者常伴有学习、记忆障碍及焦虑、抑郁等负性情绪改变,治疗困难.海马是学习、记忆及情绪反应的中枢,越来越多证据表明海马参与神经病理性疼痛的形成与维持.文章就神经病理性疼痛时,海马所发生的微观结构、形态学的改变及功能异常等进行综述,探讨海马在神经病理性疼痛中的作用,以期为神经病理性疼痛的治疗提供新思路.“,”Neuropathic pain (NP) is one of the most common chronic pain,characterized by persistent spontaneous pain,allodynia and hyperalgesia.The incidence of neuropathic pain in the general population is 7％-10％,and its pathogenesis is complex,involving the surrounding and central nervous system.Patients are often accompanied by learning,memory disorders,and anxiety,depression and other negative emotional changes,so the treatment is difficult.The hippocampus is the center of learning,memory,and emotional responses,and increasing evidence suggests that the hippocampus is involved in the formation and maintenance of neuropathic pain.In this paper,we reviewed the morphological and functional changes of hippocampus in neuropathic pain in order to explore the role of hippocampus in the treatment of neuropathic pain.